Home » Molecular Mechanism And Therapeutics Of Amyotrophic Lateral Sclerosis by Koji Abe
Molecular Mechanism And Therapeutics Of Amyotrophic Lateral Sclerosis Koji Abe

Molecular Mechanism And Therapeutics Of Amyotrophic Lateral Sclerosis

Koji Abe

Published June 11th 2001
ISBN : 9780444506139
Hardcover
396 pages
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 About the Book 

This volume covers the latest findings on the molecular mechanism and therapeutics of amyotrophic lateral sclerosis (ALS), including important research on 1) pathological characteristics and epidemiology of ALS, 2) selective vulnerability of spinalMoreThis volume covers the latest findings on the molecular mechanism and therapeutics of amyotrophic lateral sclerosis (ALS), including important research on 1) pathological characteristics and epidemiology of ALS, 2) selective vulnerability of spinal motor neurons, 3) genetic abnormality of ALS and neurotrophin, 4) mechanism of motor neuron death and glutamate toxicity, 5) motor axon, axonal transport, neurofilament, and glycation, 6) basic therapeutic approach, and 7) clinical therapeutic approach. The surprising discovery of Cu/Zn superoxide dismutase (SOD1) gene mutations in a part of familial ALS in 1993 has had a strong impact on all neuroscientists and clinicians dealing with this disease. This volume aims to help them to progress their future basic and clinical investigations, and to enhance strong scientific collaboration in elucidating the molecular mechanism and discovering the essential therapeutics of the disease.